WORLD’S MOST VERSATILE AND COST-EFFICIENT Single cell collection and tissue microdissection systems

Our products VERSATILITY AND EFFICIENCY

The company’s primary focus is in the development of instrumentation for single cell isolation and complex tissue microdissection for a range of downstream applications including genomics and single cell analysis.

About company

Collection of single cells

There is a high demand for methods permitting simple and rapid collection of individual cells or tissue regions in the numerous fields of biomedical sciences from single cell analysis and stem cell research to neuroscience and cancer diagnostics. Existing approaches are costly, sophisticated and methodologically limited.

To address this problem, NeuroInDx developed a product line of versatile instruments (UnipicK™, UnipicK+™ and A-picK™) which are based on our patented vacuum pulse based cell and tissue acquisition technology. Rapid collection of single or multiple cells can be performed from virtually any cell culture and various tissues including FFPE specimens. Our products’s versatility, cost effectiveness, streamlined operation, and cost efficiency, make them a cell collection and tissue acquisition system of choice.

alt — Single cells can be collected from any culture dish with no pretreatment and preserving cell viability. Above: Collection of a single human lung carcinoma A549 cell

Applications include but are not limited to:

Single Cell Analysis
Rare Cell Isolation
Collection of Circulating Tumor Cells (CTCs)
Stem Cell Picking
Single Cell Cloning
Clonal Expansion
Complex Tissue Microdissection
Organoid Microdissection
Acquisition of Regions of Interest (ROIs) from FFPE Specimen
Single Cell Adhesion Assay

alt — Various subanatomical regions may be easily collected from fresh frozen or native tissues. Above: CA3 hippocampal area is collected from the mouse adult brain section

Single cell or tissue area collection and deposition may be performed manually (UnipicK™, UnipicK+™) or automatically (UnipicK+™, A-picK™). The procedure is simple, rapid, and requires minimal training.

All instruments are available as free-standing versions and directly integrated with Olympus inverted microscopes (IX53, IX71, IX81, IX73 and IX83). Free standing versions utilize a patented universal straddle (US D782,554) that accommodates a range of commercially available inverted microscopes. The instruments demonstrate high consistency and accuracy of both dispensing and acquisition with no effect on cell viability.

The working concept is to collect cells and tissue regions under direct microscopic visualization by applying precise vacuum pulses into a specifically designed disposable capillary unit.

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Introduction to UnipicK+

UnipicK™ Versatile setup for cost-effective tissue microdissection

UnipicK+™ Digital control for collection and deposition of single cells

FULL AUTOMATION A-picK™ Full automation in cell and tissue acquisition

See all news

14 November 2022

Investigators from Kyoto University, Japan used UnipicK+ to measure detachment strength of HUVEC cells in response of sodium selenite concentrations. Results have important implications for in vitro construction of microvasculature.

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18 March 2022

Investigators from City University of Hong Kong used NDX instrument for the collection of individual cells from non-small lung cancer fingers for the follow-up mechanical and gene expression analysis. The study published in iScience identified genes responsible for cancer finger formation and migration.

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26 March 2021

Labeled dental primary afferent neurons were collected for RNA sequencing using UnipicK in a study uncovering mechanisms of the dental cold sensing system performed by investigators from Friedrich Alexander University of Erlangen-Nuremberg, Germany and Harvard Medical School, USA. The study was published in Science Advances.

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20 February 2021

Application of A-picK for the concurrent analysis of single cell detachment/adhesion force was published in SLAS Technology journal

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28 May 2020

UnipicK+ was used for single-cell transcriptomics study of olfactory sensory neurons to unravel mechanisms of odor encoding. The results were published in Current Biology by Firmenich investigators.

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15 May 2020

NDX technology was used in a study of Circulating Tumor Cells in Early-Stage Non-Small Cell Lung Cancer.

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NeuroInDx’s instruments are installed around the world in over hundred academic and industrial locations. We take care of our customers and provide ongoing support from the initial installation and training to protocol optimization and troubleshooting.