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WORLD’S MOST VERSATILE AND COST-EFFICIENT Single cell collection and tissue microdissection systems

Our products VERSATILITY AND EFFICIENCY

Who we are

The company’s primary focus is in the development of instrumentation for single cell isolation and complex tissue microdissection for a range of downstream applications including genomics and single cell analysis.

About company

Where it is used

There is a high demand for methods permitting simple and rapid collection of individual cells or tissue regions in the numerous fields of biomedical sciences from single cell analysis and stem cell research to neuroscience and cancer diagnostics. Existing approaches are costly, sophisticated and methodologically limited.

To address this problem, NeuroInDx developed a product line of versatile instruments (UnipicK™, UnipicK+™ and A-picK™) which are based on our patented vacuum pulse based cell and tissue acquisition technology. Rapid collection of single or multiple cells can be performed from virtually any cell culture and various tissues including FFPE specimens. Our products’s versatility, cost effectiveness, streamlined operation, and cost efficiency, make them a cell collection and tissue acquisition system of choice.

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Single cells can be collected from any culture dish with no pretreatment and preserving cell viability. Above: Collection of a single human lung carcinoma A549 cell

Applications include but are not limited to:

  • Single Cell Analysis
  • Rare Cell Isolation
  • Collection of Circulating Tumor Cells (CTCs)
  • Stem Cell Picking
  • Single Cell Cloning
  • Clonal Expansion
  • Complex Tissue Microdissection (e.g. brain)
  • Organoid Microdissection
  • Acquisition of Regions of Interest (ROIs) from FFPE Specimen
  • Single Cell Adhesion Assay
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Various subanatomical regions may be easily collected from fresh frozen or native tissues. Above: CA3 hippocampal area is collected from the mouse adult brain section

How it works

Single cell or tissue area collection and deposition may be performed manually (UnipicK™, UnipicK+™) or automatically (UnipicK+Auto™, A-picK™). The procedure is simple, rapid, and requires minimal training.

All instruments are available as free-standing versions and directly integrated with Olympus inverted microscopes (IX73 and IX83). Free standing versions utilize a patented universal straddle (US D782,554) that accommodates a range of commercially available inverted microscopes. The instruments demonstrate high consistency and accuracy of both dispensing and acquisition with no effect on cell viability.

The working concept is to collect cells and tissue regions under direct microscopic visualization by applying precise vacuum pulses into a specifically designed disposable capillary unit.

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News and events

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UnipicK+ was used for single-cell transcriptomics study of olfactory sensory neurons to unravel mechanisms ofodor encoding. The results were published in Current Biology by Firmenich investigators.

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NDX technology was used in a study of Circulating Tumor Cells in Early-Stage Non-Small Cell Lung Cancer.

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NDX technology was used in a single cell transcriptional analysis of tumor cell clusters in epithelial ovarian cancer.

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Single cells were isolated using NDX instrument in a study of individual CTCs associated with tumor progression during EGFR-targeted therapy.

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NDX exhibits its products at the 64th Annual Meeting of Biophysical Society in San Diego.

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A new study “Rapid and ultrasensitive digital PCR (dPCR) profiling of EGFRvIII in tumor cells and tissues” published in Neuro Oncology Advances uses NeuroInDx technology to collect individual cells.

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Support

NeuroInDx’s instruments are installed around the world in over hundred academic and industrial locations. We take care of our customers and provide ongoing support from the initial installation and training to protocol optimization and troubleshooting.

  • Free on-site installation
  • Free on-site training
  • Worldwide shipping and delivery
  • Life-time free technical support
  • Three years full warranty

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Our clients

100+

Clients around the world, including the top universities, best medical schools, independent research centers, pharmaceutical and biotech companies.

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